Matthew Q. Salzano

Matthew Q. Salzano

Researcher

Biography

Hello and welcome to page! My name is Matt Salzano and I am a trained scientist with about a decade of experience in conducting research and an educational background in physiology and kinesiology. I have led and executed 10+ studies, gaining experience in all phases of research: design and implementation, troubleshooting, data collection, data and statistical analyses, and communication. I have also presented my work in podium and poster formats at 10+ conferences, and have even won awards for my work on two occaisons.

Through my research, I found my passion was in writing code to clean, consolidate, and manipulate data into its final form, and subsequently running the necessary statistical analyses to learn from the data. I have enjoyed teaching myself about predictive modeling and machine learning techniques, and I am eager to expand my knowledge of the data science field. I also pride myself on my ability to create effective presentations and publications to communicate findings.

Outside of work, I enjoy spending time with girlfriend, my family, and my dog Moose. I also like to spend my time in the kitchen honing my skills and experimenting with new recipes. Although I like to watch most sports, I am an avid soccer and college football fan.

Download my resumé (link currently broken).

Click on the icons to the left to follow links to my Google Scholar, GitHub, and LinkedIn.

Research Background

Currently, I am an associate statistical programmer for Pfizer - a role I transitioned to after completing an internship with Pfizer during the summer of 2022. As a programmer, I am leveraging my skills in R in order to develop code to QC biomarker TLFs (typically produced in SAS) from clinical trial data. I have also fulfilled requests to deliver analysis-ready datasets and anonymize clinical trial data for external researchers. As an intern, I worked to extract drug efficacy metadata from clinical trial SAPs, CSRs, and LoTs. My experience at Pfizer in my two roles has been invaluable to introducing me to the world of pharmaceutical research.

Prior to my first step into industry, I was a postdoctoral research associate at the University of Massachusetts Amherst in the Department of Kinesiology under the guidance of Dr. Joseph Hamill. At UMass, I worked with an industry partner to perform footwear and running research. One of my two main projects was to use motion capture and force analysis to evaluate running biomechanics between prototype running shoes in order to inform on future designs. My second main project was to use data analysis and data science techniques to build a predictive model of runner satisfaction in footwear from its mechanical properties. It was this latter project where I developed a passion for data science. I also ran the statistical analyses for a study quantifying injuries during trail running.

Before my postdoc, I was a doctoral student of Dr. Jonas Rubenson at Penn State University. At Penn State, I worked on a NIH R21 grant in collaboration with scientists that had backgrounds in biomechanics, physiology, engineering, and anthropology. The purpose of the grant was to study musculoskeletal adaptations to loading history during growth using an avian bipedal model. We were interested in studying if exercise performed during childhood and adolescent years affected the structure of the musculoskeletal system, thereby influencing an adult’s locomotor performance. Specifically, I studied how high-acceleration training during growth affected muscle architecture and bone morphology, as well as how reduced loading (i.e. induced muscle paralysis via botox injections) influenced muscle moment arms. I also assisted our postdoc in the lab, Dr. Suzanne Cox, in the development of a soft exosuit (for guineafowl) in order to study neuromuscular adaptation to their use. Outside of research, I was a lead teaching assistant for 2 sections per semester for various anatomy labs. I taught an introductory cadaver-based anatomy lab for 6 semesters, an advanced cadaver-based anatomy lab for 1 semester, and an introductory anatomy & physiology lab for 1 semester.

My graduate school experience started with getting my master’s degree in kinesiology at East Carolina University, under the direction of Dr. Zac Domire. My work at ECU focused on the effects of muscle stiffness on health and injury. My thesis project investigated a possible link between muscle stiffness and sarcopenia (i.e. muscle wasting in old age), with the theory that stiffer muscles impair the cellular response to exercise that promotes muscle growth or maintenance. I also worked with the track & field team at ECU to probe if hamstring strains could be predicted using ultrasound elastography, where areas of potential injury would show drastically different stiffness values than other areas. My teaching experience started at ECU, where I taught 3 sections per semester of a lecture-based functional anatomy class.

Interests
  • Data Science
  • Data Analysis
  • Statistical Programming
  • Musculoskeletal Biomechanics
  • Musculoskeletal Physiology
  • Human Health
Education
  • PhD in Integrative & Biomedical Physiology, 2020

    Penn State University

  • MS in Kinesiology (Biomechanics concentration), 2015

    East Carolina University

  • BS in Exercise Physiology, 2009

    East Carolina University

Experience

 
 
 
 
 
Postdoctoral Research Associate
University of Masschusetts Amherst
Aug 2020 – Sep 2021 Amherst, MA
  • Developed predictive models in R using machine learning algorithms (random forest, elastic net logistic regression) to predict runner satisfaction from footwear mechanical properties with up to 70% accuracy
  • Applied clustering algorithms to biomechanical and GPS watch data in R to identify types of runners
  • Ran statistical analyses (Chi-square, marginal independence tests) on a sizeable survey dataset in R to determine injury occurrence across various trail and terrain types
  • Performed an exploratory data analysis and ran statistical analyses (linear & nonlinear regression, multivariate mixed models) on a GPS watch dataset in Python and R to determine if running patterns are altered by time of day
  • Wrote code to clean, manipulate, and merge various datasets using R, Python, MATLAB, and SQL
  • Generated data analysis reports in Microsoft PowerPoint and presented findings to industry partners
  • Built RShiny app to visualize simulated footwear, biomechanics, perception, and subject data
  • Collected and analyzed biomechanical (motion capture, force plate) and perceptual data for multiple research studies evaluating prototype running shoes in order to inform on future designs for an industry partner
  • Co-authored and edited 3 peer-reviewed journal publications and 2 abstracts for an international conference
 
 
 
 
 
Graduate Research Assistant
The Pennsylvania State University
Aug 2015 – May 2020 University Park, PA
  • Designed, troubleshooted, and executed experimental protocols for a multidisciplinary NIH R21 grant studying musculoskeletal adaptations in response to loading history during growth in an avian bipedal model
  • Analyzed data in MATLAB and ran statistical analyses (ANOVAs, linear mixed models, principal components analysis) in R to determine exercise effects on the musculoskeletal system
  • Utilized medical imaging modalities (microCT, MRI, X-ray) to study the structure of the musculoskeletal system
  • Mentored junior lab members and provided instruction on various lab and research techniques
  • Co-authored and edited 4 peer-reviewed journal publications and 8 abstracts for scientific conferences
  • Presented 7 podium and poster conference presentations created in Microsoft PowerPoint and Adobe Illustrator
  • Taught 16 sections over 8 semesters of introductory- and advanced-level cadaver-based human anatomy labs
 
 
 
 
 
Graduate Research Assistant
East Carolina University
Aug 2013 – Jun 2015 Greenville, NC
  • Led a study to determine if muscle stiffness, as measured by ultrasound elastography, can predict hamstring injury in elite track & field athletes
  • Investigated a link between sarcopenia and reduced cellular response to resistance training in a rodent model using material testing and Western blot analyses
  • Tested muscle fatigue between dominant and non-dominant legs for a class project using isokinetic dynamometry and electromyography
  • Processed and analyzed data using MATLAB and ran statistical analyses in SPSS
  • Lectured 13 sections over 5 semesters of lecture-based, exercise-related functional anatomy course

Projects

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Journal Publications

Quickly discover relevant content by filtering publications.
(2022). The Prevalence of Injuries in Trail Running: Influence of Trails, Terrains and Footwear. In *Footwear Science *.

DOI

(2021). Plasticity of the gastrocnemius elastic system in response to decreased work and power demand during growth. In Journal of Experimental Biology.

DOI

(2021). Comparing Leg Quasi-Stiffness Methods Across Running Velocities. In Journal of Applied Biomechanics.

DOI

(2020). Altering the Mechanical Load Environment During Growth Does Not Affect Adult Achilles Tendon Properties in an Avian Bipedal Model. In *Frontiers in Bioengineering and Biotechnology *.

DOI

(2020). Eliminating high-intensity activity during growth reduces mechanical power capacity but not submaximal metabolic cost in a bipedal animal model. In Journal of Applied Physiology.

DOI

Featured Conference Presentations

Quickly discover relevant content by filtering publications.
(2021). Can We Predict Cushioning Perception from the Mechanical Properties of Shoes? . 15th Biennial Footwear Biomechanics Symposium (Virtual Conference).

PDF Slides

(2020). Moment Arm Plasticity in Response to Loading History During Growth. 44th Annual Meeting of the American Society of Biomechanics (Virtual Conference).

PDF Slides

(2019). Effects of Exercise During Growth on Bone Strength and Morphology. 43rd Annual Meeting of the American Society of Biomechanics (Calgary, Canada).

PDF Poster Slides

(2018). Impaired Jumping Performance Arising from Sedentary Growth is Recovered through Exercise in Adulthood. 42nd Annual Meeting of the American Society of Biomechanics (Rochester, MN).

PDF Poster

(2018). Impaired Jumping Performance Arising from Sedentary Growth is Recovered through Exercise in Adulthood. 1st Annual Meeting of the American Society of Biomechanics - East Coast Meeting (Reading, PA).

PDF Poster

(2017). High-acceleration training during growth increases optimal fiber lengths in an avian bipedal model. 41st Annual Meeting of the American Society of Biomechanics (Boulder, CO).

PDF Slides

(2016). The effect of disuse on muscle lever systems in a rapid-growing avian bipedal model. 40th Annual Meeting of the American Society of Biomechanics (Raleigh, NC).

PDF

(2015). Hamstring Shear Modulus is Altered Prior to Strain Injury: A Case Study. 25th Congress of the International Society of Biomechanics (Glasgow, Scotland).

PDF

Awards & Honors

AMTI Best Poster Award - Graduate Student
  • Awarded to the most highly rated poster amongst graduate students
  • Received $100 gift card
Journal of Biomechanics Award
  • Awarded to the winner of a podium competition between the two highest-rated abstracts submitted
  • Received $1000 prize money and an invited publication to the Journal of Biomechanics
University Graduate Fellowship
  • Awarded to 100 incoming graduate students based on academic record, GRE scores, and letters of recommendation
  • Received a stipend of $26,250 per year for first two years of study
Robert W. Graham Endowed Fellowship
  • Awarded to outstanding incoming graduate students to provide stipend supplementation * Received $4,000 per year for first two years of study
Graduate Scholar Award
  • Awarded to outstanding incoming graduate students
  • Received $4,000 per year for first two years of study
Graduate Scholar Award
  • Awarded to outstanding incoming graduate students
  • Received $4,000 per year for first two years of study
Chancellor’s List
  • Earned in Spring 2010, Fall 2010, Spring 2012
  • Awarded to undergraduate students that obtain a 4.00 GPA for a given semester
Dean’s List
  • Earned in Fall 2009, Spring 2011, Fall 2011
  • Awarded to undergraduate students that obtain a 3.50 GPA for a given semester

Skills

R
Python
MATLAB
Statistics
Data Analysis
Public Speaking & Teaching
Microsoft Excel
Microsoft Powerpoint
Microsoft Word
Scientific Writing
Anatomy & Physiology

Contact